Peer-reviewed veterinary case report
Different immune cells mediate mechanical pain hypersensitivity in male and female mice.
- Journal:
- Nature neuroscience
- Year:
- 2015
- Authors:
- Sorge, Robert E et al.
- Affiliation:
- 1] Department of Psychology · United States
- Species:
- rodent
Abstract
A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26120961/