Differential Effects ofandvar.Extracts on Liver Steatosis in a Murine Dietary Model.

Abstract

: Metabolic-dysfunction-associated fatty liver disease (MASLD) is characterised by an excessive hepatic lipid accumulation. The present research aims to study the impact of anvar.peel extract and anvar.pulp extract, known for their high content of betalains and phenolic compounds, on the prevention of hepatic lipid accumulation in the liver of rats with steatosis.: For this, MASLD was induced in 60 male Wistar rats by a high-fat high-fructose diet. They were supplemented withvar.peel extract orvar.pulp extract at 25 or 100 mg/kg body weight/d.: The high-fat high-fructose diet caused an increase in final body and liver weight, hepatic triglyceride (TG) content, and altered liver histology. The increase in hepatic TG was due to the rise in fatty acid uptake and the increased assembly of TG, although increasedlipogenesis cannot be ruled out. The treatment with a low dose ofvar.pulp extract (L-OFI group) significantly prevented hepatic TG accumulation, and the high dose (H-OFI group) showed a tendency towards lower values compared to the rats fed the high-fat high-fructose diet. The main mechanism of action appears to be a down-regulation of fatty acid uptake. By contrast,var.peel extract did not prevent the high-fat high-fructose diet-induced steatosis.: Overall,var.pulp extract may represent a potential strategy for MASLD prevention, although its beneficial effects require confirmation in human studies.