Peer-reviewed veterinary case report
Differential efficacy of clarithromycin in lung versus thigh infection models.
- Journal:
- Chemotherapy
- Year:
- 2004
- Authors:
- Maglio, Dana et al.
- Affiliation:
- Hartford Hospital · United States
Abstract
BACKGROUND: Differences in clarithromycin disposition and the resulting changes in bacterial density were studied using mouse lung and thigh infection models. METHODS: Clarithromycin activity was evaluated against seven Streptococcus pneumoniae isolates with efflux-mediated resistance in both murine lung and thigh infection models. Intrapulmonary disposition of clarithromycin was also studied. RESULTS: Consistent bacterial kill was observed in the lung model, whereas no drug effect was observed in the thigh model. CONCLUSION: These differences in bacterial density were supported by high concentrations observed in epithelial lining fluid as compared to serum.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15211079/