Peer-reviewed veterinary case report
Differential gene expression in central nervous system tissues of sheep with natural scrapie.
- Journal:
- Brain research
- Year:
- 2006
- Authors:
- Garcia-Crespo, David et al.
- Affiliation:
- Department of Animal Health · Spain
Abstract
The expression of nine genes was analyzed by real-time RT-PCR in the central nervous system in order to investigate the molecular pathogenesis of natural scrapie. An up-regulation of genes related to glial activation (GFAP) and apoptosis (CASP3) was detected in obex and cerebrum, indicating a reactive glia. Another glial activation-related gene (CTSS) was slightly up-regulated in obex, whereas constitutive expression was detected for SOD1, YWHAZ, PRNP, and the apoptosis-related genes BCL2, MCL1, and BAX. This differential gene expression might reflect a spatial-temporal and tissue-specific molecular pathogenesis of scrapie.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16458864/