Peer-reviewed veterinary case report
Genetic differences linked to hip dysplasia and arthritis in dogs
By Zhou, Zhengkui et al.·Published in PloS one·2010·College of Animal Science and Technology, China·View original on PubMed →
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Original publication title: Differential genetic regulation of canine hip dysplasia and osteoarthritis.
- Species:
- dog
Plain-English summary
A study looked at hip dysplasia and osteoarthritis in dogs, which are common conditions that can cause pain and mobility issues. Researchers examined the genetics of 721 dogs from various breeds, including Labrador Retrievers and German Shepherds, to identify specific genetic markers linked to these conditions. They found several genetic variations that could help explain why some dogs develop hip dysplasia and osteoarthritis. Understanding these genetic factors may lead to better prevention and treatment options for affected dogs in the future.
People also search for: dog hip dysplasia symptoms · Labrador Retriever osteoarthritis treatment · genetic testing for dog hip problems
Abstract
BACKGROUND: Canine hip dysplasia (HD) is a common polygenic trait characterized by hip malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human hip which also leads to OA. METHODOLOGY/PRINCIPAL FINDINGS: A total of 721 dogs, including both an association and linkage population, were genotyped. The association population included 8 pure breeds (Labrador retriever, Greyhounds, German Shepherd, Newfoundland, Golden retriever, Rottweiler, Border Collie and Bernese Mountain Dog). The linkage population included Labrador retrievers, Greyhounds, and their crosses. Of these, 366 dogs were genotyped at ∼22,000 single nucleotide polymorphism (SNP) loci and a targeted screen across 8 chromosomes with ∼3,300 SNPs was performed on 551 dogs (196 dogs were common to both sets). A mixed linear model approach was used to perform an association study on this combined association and linkage population. The study identified 4 susceptibility SNPs associated with HD and 2 SNPs associated with hip OA. CONCLUSION/SIGNIFICANCE: The identified SNPs included those near known genes (PTPRD, PARD3B, and COL15A1) reported to be associated with, or expressed in, OA in humans. This suggested that the canine model could provide a unique opportunity to identify genes underlying natural HD and hip OA, which are common and debilitating conditions in both dogs and humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20949002/