Peer-reviewed veterinary case report
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
- Journal:
- The Journal of experimental medicine
- Year:
- 2008
- Authors:
- Saito, Takeshi & Gale, Michael
- Affiliation:
- Department of Immunology · United States
Abstract
Retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) are cytosolic RNA helicases that sense viral RNA and trigger signaling pathways that induce the production of type I interferons (IFNs) and proinflammatory cytokines. RLRs recognize distinct and overlapping sets of viruses, but the mechanisms that dictate this specificity were unknown. A new study now provides evidence for size-based discrimination of double-stranded RNA (dsRNA) by RLRs and suggests how host cells recognize a variety of RNA viruses.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18591413/