Peer-reviewed veterinary case report
Differentiating blood samples from scrapie infected and non-infected hamsters by detecting disease-associated prion proteins using Multimer Detection System.
- Journal:
- Biochemical and biophysical research communications
- Year:
- 2010
- Authors:
- An, S S A et al.
- Affiliation:
- Department of Bionano Technology · South Korea
- Species:
- rodent
Abstract
This communication describes the application of a modified sandwich enzyme-linked immunosorbent assay (ELISA), termed Multimer Detection System (MDS) for the detection of disease-associated multimeric forms of the prion protein (PrPd) in hamster blood. PrPd was detected in plasma of prion-affected hamsters while MDS revealed no PrPd in identically-treated plasma of healthy animals. This is the first report of a single ELISA- based immune detection of PrPd from blood samples.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20085753/