Peer-reviewed veterinary case report
How to tell pyometra from cystic endometrial hyperplasia in bitches
By Hagman, R et al.·Published in Theriogenology·2006·Department of Small Animal Clinical Sciences·View original on PubMed →
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Original publication title: Differentiation between pyometra and cystic endometrial hyperplasia/mucometra in bitches by prostaglandin F2alpha metabolite analysis.
Plain-English summary
A group of female dogs with suspected uterine infections were tested to see if a specific blood marker could help tell the difference between two serious conditions: pyometra (a severe infection of the uterus) and cystic endometrial hyperplasia (a less severe condition). The study found that dogs with pyometra had much higher levels of this marker in their blood compared to those with the other condition. Using this marker alone was very effective, but combining it with another blood test made the diagnosis even more accurate. This means that if your dog has high levels of this marker, it’s very likely she has pyometra, which is a condition that needs urgent treatment.
People also search for: dog pyometra symptoms · how to treat pyometra in dogs · cystic endometrial hyperplasia in dogs
Abstract
Bitches with pyometra are potential emergency cases which may be clinically difficult to differentiate from cases of cystic endometrial hyperplasia (CEH) in combination with mucometra. In the present study plasma prostaglandin F(2alpha), as measured by its main metabolite 15-keto-13,14-dihydro-PGF(2alpha) (PG-metabolite) concentrations, blood biochemical and hematological parameters were measured in 59 bitches with pyometra, 10 bitches with CEH and nine controls to determine if PG-metabolite could differentiate between the three uterine conditions. Bitches with pyometra had significantly higher plasma levels of PG-metabolite than bitches with CEH (P=0.002) and the controls (P=0.002). PG-metabolite analysis alone had a high sensitivity (98.3%) and a high specificity (80.0%) for the differentiation of pyometra versus CEH in bitches where fluid in the uterus was diagnosed. When a combination of PG-metabolite and percentage band neutrophils (PBN) was used for differentiation of the two diagnoses, a sensitivity of 100% and specificity of 90.0% was obtained. This means that the combination of PG-metabolite and PBN analysis allows for differentiation between cases of pyometra and CEH. If the PG-metabolite level in a bitch is >or=4,524 pmol l(-1), there is a 99% probability of the diagnosis pyometra versus CEH. Levels of PG-metabolite >or=3,054 pmol l(-1), >or=2,388 pmol l(-1) or>or=1,666 pmol l(-1) indicates a 95%, 90% or 80% probability of pyometra, respectively. At high PG-metabolite levels (above about 3,000 pmol l(-1)), PG-metabolite alone is enough for differentiation of pyometra versus CEH. The results of the present study showed that PG-metabolite analysis is valuable in the diagnosis and prediction of severity of uterine diseases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16375957/