Peer-reviewed veterinary case report
Differentiation of rat mesenchymal stem cells transplanted into the subretinal space of sodium iodate-injected rats.
- Journal:
- Clinical & experimental ophthalmology
- Year:
- 2008
- Authors:
- Gong, Lihua et al.
- Affiliation:
- Department of Ophthalmology · China
- Species:
- rodent
Abstract
PURPOSE: The differentiation of rat bone marrow mesenchymal stem cells (MSCs) was investigated in a retinal pigment epithelium (RPE) damage model induced by the administration of sodium iodate. METHODS: Cultured rat MSCs were transfected with enhanced green fluorescent protein and transplanted into the subretinal space of rats injected 4 days earlier with sodium iodate. Immunofluorescence analysis was performed 5 weeks later. RESULTS: The transduction efficiency was 99.9%. Viable MSCs were detected 5 weeks after transplantation, mainly in the subretinal space. The cells expressed pan-cytokeratin, glial fibrillary acidic protein and rhodopsin. CONCLUSIONS: Bone marrow MSCs transplanted into the subretinal space of sodium iodate-injected rats have the ability to differentiate into RPE, photoreceptor and glial lineage cells.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18983552/