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Peer-reviewed veterinary case report

Diffuse cerebral encephalopathy associated with hydrocephalus and cholesterinic granulomas in a horse.

Journal:
Journal of the American Veterinary Medical Association
Year:
1993
Authors:
Johnson, P J et al.
Affiliation:
Department of Veterinary Clinical Sciences
Species:
horse

Plain-English summary

In older horses, a type of growth called cholesterinic granulomas can sometimes block fluid pathways in the brain, leading to a condition known as hydrocephalus, where fluid builds up. This can cause various neurological symptoms, but these symptoms might not always get worse quickly. Instead, they can come and go, possibly due to changes in the pressure of the fluid around the brain. The study highlights that while these issues can be serious, the progression of symptoms can vary significantly.

Abstract

Cholesterinic granulomas, commonly found at necropsy in aged horses, may cause neurologic signs by obstructing the interventricular foramina, resulting in hydrocephalus. Diffuse cerebral disease in horses may not always result in rapid progression of clinical signs. Intermittency of neurologic signs may be associated with intermittent increases in CSF pressure.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/8407539/