Peer-reviewed veterinary case report
Diluting Cerenia with lactated Ringer slows absorption in dogs
By Yee, Deborah E et al.Ā·Published in Journal of the American Veterinary Medical AssociationĀ·2023Ā·View original on PubMed ā
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Original publication title: Dilution of maropitant (Cerenia) in lactated Ringer solution prolongs subcutaneous drug absorption and reduces maximum plasma concentration.
- Species:
- dog
Plain-English summary
Six Beagle dogs were given an injection of maropitant (Cerenia), a medication used to prevent vomiting, either on its own or diluted in a fluid called lactated Ringer solution. When the medication was diluted, it took longer for the drug to be absorbed into the bloodstream and reached lower peak levels. While this study didn't look at how well the medication worked in preventing vomiting, the findings suggest that diluting Cerenia may change how quickly it acts in dogs.
People also search for: dog vomiting treatment Ā· Cerenia dosage for dogs Ā· Beagle vomiting medication
Abstract
OBJECTIVE: The aim of this study was to determine whether the pharmacokinetics of maropitant, administered SC as a commercially available maropitant-containing injectable product (Cerenia Injectable), differ when combined with lactated Ringer solution prior to administration. ANIMALS: We used 6 adult spayed female Beagle dogs between 3 and 6 years of age, with a mean weight of 9.58 kg. PROCEDURES: In this randomized crossover study, the dogs underwent 2 treatment protocols separated by a 14-day washout period: (1) an SC injection of 1 mg/kg of Cerenia Injectable (maropitant citrate; 10 mg/mL) and (2) 1 mg/kg of Cerenia Injectable diluted in 10 mL/kg of lactated Ringer injectable solution (LRS) given SC. Plasma maropitant concentrations were assessed by mass spectrometry. Pharmacokinetic analysis was performed using pharmacokinetic and pharmacodynamic data-analysis software to determine maximum plasma concentration (Cmax), time to reach maximum concentration, half-life, total exposure to the drug, mean residence time, clearance rate per fraction absorbed, and absorption and elimination kinetic parameters. RESULTS: Cmax was reduced by 26% (P = .002), the absorption rate constant decreased 80% (P = .031), and the absorption half-life increased when Cerenia was administered diluted in LRS. CLINICAL RELEVANCE: Administration of maropitant (Cerenia) diluted in LRS had a pharmacokinetic impact, resulting in a significantly reduced Cmax and slower absorption. Clinical efficacy was not assessed in this study.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36884379/