Peer-reviewed veterinary case report
Diminazene aceturate controls Trypanosoma evansi infection in cats
By Da Silva, A S et al.·Published in Veterinary parasitology·2009·Department of Microbiology and Parasitology, Brazil·View original on PubMed →
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Original publication title: Diminazene aceturate in the control of Trypanosoma evansi infection in cats.
- Species:
- cat
Plain-English summary
A group of infected cats showed symptoms from a Trypanosoma evansi infection, which can cause various health issues. Seven of these cats were treated with a medication called diminazene aceturate for five days. The treatment was highly effective, with an 85.7% success rate, and the cats' blood tests returned to normal afterward. This means that diminazene aceturate can be a good option for treating this specific infection in cats.
People also search for: cat Trypanosoma evansi infection treatment · diminazene aceturate for cats · symptoms of Trypanosoma evansi in cats
Abstract
The aim of this study was to investigate the efficacy of diminazene aceturate in the control of the infection by Trypanosoma evansi in cats. Fourteen animals were infected with 10(8) trypomastigote forms each and six were used as negative control (group A). Seven of the infected cats were used as positive control (group B) and seven were treated with diminazene aceturate (3.5 mg kg(-1)) for 5 consecutive days (group C). Biochemical and hematological parameters were evaluated during the experiment. Blood with anticoagulant was collected at day 49 post-inoculation and preserved in ethanol for DNA extraction. Samples were analyzed using PCR T. evansi-specific to assess the effectiveness of treatment. The treatment with diminazene aceturate had an efficacy of 85.7%. Alanine aminotransferase, gamma-glutamyltransferase, urea, and creatinine values remained within the normal physiological range in the treated cats. Hemogram was normalized in all the cured animals. Therefore, the therapy used is effective in controlling T. evansi in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19631469/