Peer-reviewed veterinary case report
Cat with mismatched blood type test and gene results
By Ginoudis, Argyrios et al.·Published in Journal of veterinary internal medicine·2024·School of Veterinary Medicine·View original on PubMed →
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Original publication title: Discordance between ABC blood phenotype and genotype in a domestic short-haired cat.
- Species:
- cat
Plain-English summary
A domestic short-haired cat with feline leukemia virus was brought in for kidney failure and severe anemia, which required blood transfusions. Blood typing tests showed confusing results, as the cat did not show typical blood type A or B markers, but its blood was compatible with some type A and B donors. Further genetic testing indicated that the cat likely had a rare blood type variant. Despite the challenges with blood compatibility, the cat received appropriate transfusions and treatment for its kidney issues.
People also search for: cat kidney failure treatment · cat anemia symptoms · cat blood transfusion compatibility
Abstract
An adult domestic short-haired feline leukemia virus-infected cat was referred for kidney failure and worsening anemia requiring transfusions. ABC blood typing was performed with an immunochromatographic strip assay at different occasions. Gel column systems were used for the major and minor crossmatching tests, and anti-A and anti-B titers were determined. No discrete A or B bands appeared on the immunochromatographic strips at any time point for the recipient cat. The recipient's plasma agglutinated RBCs from tested type A and B cats. The recipient's RBCs appeared compatible with plasma from 1 type A and 2 B donors, and incompatible with plasma from another type A cat. Genotyping of recipient blood revealed a single homozygous c.179G>T CMAH variant predicting a blood type B. These studies suggest an unusual weak type B or missing all ABC antigens. The latter resembles the exceedingly rare Bombay phenotype in the human ABO blood group system.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37921544/