Peer-reviewed veterinary case report
New canine respiratory coronavirus strain found in dog
By Lu, Shuai et al.·Published in Virus research·2017·Institute of Medical Virology, China·View original on PubMed →
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Original publication title: Discovery of a novel canine respiratory coronavirus support genetic recombination among betacoronavirus1.
- Species:
- dog
Plain-English summary
A dog with a mild respiratory infection tested positive for a new strain of canine respiratory coronavirus (CRCoV), which researchers named BJ232. This strain is related to both human and bovine coronaviruses, suggesting it may have originated from genetic mixing between these viruses. The study highlights the importance of understanding how CRCoV can change and spread, which could affect how it is transmitted among dogs. While the dog recovered from its mild symptoms, the findings emphasize the need for ongoing monitoring of respiratory viruses in pets.
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Abstract
Although canine respiratory coronavirus (CRCoV) is an important respiratory pathogen that is prevalent in many countries, only one complete genome sequence of CRCoV (South Korea strain K37) has been obtained to date. Genome-wide analyses and recombination have rarely been conducted, as small numbers of samples and limited genomic characterization have previously prevented further analyses. Herein, we report a unique CRCoV strain, denoted strain BJ232, derived from a CRCoV-positive dog with a mild respiratory infection. Phylogenetic analysis based on complete genome of all available coronaviruses consistently show that CRCoV BJ232 is most closely related to human coronavirus OC43 (HCoV-OC43) and BCoV, forming a separate clade that split off early from other Betacoronavirus 1. Based on the phylogenetic and SimPlot analysis we propose that CRCoV-K37 was derived from genetic recombination between CRCoV-BJ232 and BCoV. In detail, spike (S) gene of CRCoV-K37 clustered with CRCoV-BJ232. However orf1ab, membrane (M) and nucleocapsid (N) genes were more related to Bovine coronavirus (BCoV) than CRCoV-B232. Molecular epidemic analysis confirmed the prevalence of CRCoV-BJ232 lineage around the world for a long time. Recombinant events among Betacoronavirus 1 may have implications for CRCoV transmissibility. All these findings provide further information regarding the origin of CRCoV.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28506792/