Peer-reviewed veterinary case report
Discovery of a novel series of nonacidic benzofuran EP1 receptor antagonists.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2011
- Authors:
- Allan, Amanda C et al.
- Affiliation:
- Neurosciences Centre of Excellence for Drug Discovery · United Kingdom
Abstract
We describe the discovery and optimization of a novel series of benzofuran EP(1) antagonists, leading to the identification of 26d, a novel nonacidic EP(1) antagonist which demonstrated efficacy in preclinical models of chronic inflammatory pain.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21676612/