Peer-reviewed veterinary case report
Discovery of a potent, orally bioavailable pyrimidine VLA-4 antagonist effective in a sheep asthma model.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2011
- Authors:
- Semko, Christopher M et al.
- Affiliation:
- Elan Pharmaceuticals · United States
Abstract
A series of N-(pyrimidin-4-yl)-phenylalanine VLA-4 antagonists is described. Optimization of substituents at the 2 and 5 positions of the pyrimidine ring gave 14, a very potent VLA-4 inhibitor which is orally active in a sheep asthma model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21316228/