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Peer-reviewed veterinary case report

Discovery of Coracanols A and B, Two Biological Nitrification Inhibition Diterpenoids from Finger Millet.

Year:
2026
Authors:
Otaka J et al.
Affiliation:
Biological Resources and Post-harvest Division · Japan

Abstract

Natural products with biological nitrification inhibition (BNI) activity released from plant roots show potential for increasing the nitrogen-use efficiency and decreasing the extent of environmental pollution. We isolated two diterpenoids, coracanols A (<b>1</b>) and B (<b>2</b>), from finger millet grown under low-nitrogen conditions. Both compounds showed BNI activity against nitrifying bacterium <i>Nitrosomonas europaea</i>. The novel skeletons (<b>1</b> and <b>2</b>) featuring a tetracyclo[10.2.2.0<sup>1,10</sup>.0<sup>2,7</sup>]hexadecane core were elucidated by spectroscopic and X-ray crystal structure analyses utilizing the crystalline sponge method.

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Original publication: https://europepmc.org/article/MED/41801814