Peer-reviewed veterinary case report
Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agents.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2009
- Authors:
- Hosoda, Shinnosuke et al.
- Affiliation:
- Institute of Molecular & Cellular Biosciences · Japan
Abstract
Based on antiviral screening of our diphenylmethane derivatives prepared as steroid substitutes, we identified a 1,1-diphenylcyclobutane analog (9) and two diethyldiphenylsilane analogs (12 and 13) as superior lead compounds with potent anti-bovine viral diarrhea virus (BVDV) activity, having 50% effective concentration (EC(50): based on reduction of BVDV replication-induced cell destruction) and 50% cytotoxic concentration (CC(50): based on reduction of viable cell number) values of 6.2-8.4 microM and >100 microM, respectively, in Madin-Darby bovine kidney (MDBK) cells infected with BVDV.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19447037/