Peer-reviewed veterinary case report
Discovery of DS34942424: An orally potent analgesic without mu opioid receptor agonist activity.
- Journal:
- Bioorganic & medicinal chemistry
- Year:
- 2020
- Authors:
- Arita, Tsuyoshi et al.
- Affiliation:
- Medicinal Chemistry Research Laboratories · Japan
- Species:
- rodent
Abstract
We identified (5'S)-10'-fluoro-6'-methyl-5',6'-dihydro-3'H-spiro[cyclopropane-1,4'-[2,6]diaza[2,5]methano[2,6]benzodiazonin]-7'(1'H)-one, 22b (DS34942424) with a unique and original bicyclic skeleton. 22b showed an orally potent analgesic in the acetic acid-induced writhing test and formalin test in ddY mice without sedation. Moreover, 22b did not exhibit mu opioid receptor agonist activity.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33065431/