Peer-reviewed veterinary case report
Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2004
- Authors:
- Chen, Ping et al.
- Affiliation:
- Department of Discovery Chemistry · United States
Abstract
A series of substituted 2-(aminoheteroaryl)-thiazole-5-carboxamide analogs have been synthesized as novel, potent inhibitors of the Src-family kinase p56Lck. Among them, compound 2 displayed superior in vitro potency and excellent in vivo efficacy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15546730/