Peer-reviewed veterinary case report
Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2009
- Authors:
- Mitsuya, Morihiro et al.
- Affiliation:
- Banyu Tsukuba Research Institute · Japan
- Species:
- rodent
Abstract
A novel class of 3,6-disubstituted 2-pyridinecarboxamide derivatives was designed based on X-ray analysis of the 2-aminobenzamide lead class. Subsequent chemical modification led to the discovery of potent GK activators which eliminate potential toxicity concerns associated with an aniline group of the lead structure. Compound 7 demonstrated glucose lowering effect in a rat OGTT model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19362831/