Peer-reviewed veterinary case report
How to tell Wells-like and Sweet's-like skin syndromes apart in dogs
By Bradley, Charles W et al.·Published in Veterinary dermatology·2019·Department of Pathobiology, United States·View original on PubMed →
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Original publication title: Discriminatory features of acute eosinophilic dermatitis with oedema (Wells-like syndrome) and sterile neutrophilic dermatosis (Sweet's-like syndrome) in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with skin problems were diagnosed with either acute eosinophilic dermatitis (a condition causing swelling and itching) or sterile neutrophilic dermatosis (a skin condition often linked to immune issues). The study found that dogs with eosinophilic dermatitis often showed gastrointestinal symptoms and itching, while those with neutrophilic dermatosis had a higher chance of joint pain. The researchers used special staining techniques to help identify the conditions. Understanding these differences can help veterinarians provide better treatment options for affected dogs.
People also search for: dog skin problems itching · eosinophilic dermatitis treatment dogs · dog joint pain immune issues
Abstract
BACKGROUND: Canine acute eosinophilic dermatitis with oedema (CAEDE) and sterile neutrophilic dermatosis have overlapping clinical and histopathological features. HYPOTHESIS/OBJECTIVES: The objective of this study was to identify features that differentiate these entities. ANIMALS: Forty dogs. METHODS AND MATERIALS: Retrospective case series. Forty cases with diagnoses of either CAEDE and/or sterile neutrophilic dermatosis were included based on histopathological review. Medical records (29 of 40 dogs) were reviewed for clinical findings and historical data. Commercially available immunohistochemical stains for granulocytes and a Luna stain were performed (40 of 40 dogs) to assess the granulocytic infiltrate. RESULTS: Nineteen cases had been previously diagnosed as CAEDE, seven cases had been designated as sterile neutrophilic dermatosis and 14 cases had overlapping features. Based on review and receiver operating characteristic (ROC) curve analysis, 30 cases with >12% eosinophils, enumerated by Luna staining, were diagnosed as eosinophilic dermatitis and oedema. Ten cases were diagnosed as sterile neutrophilic dermatosis. Dogs with CAEDE frequently had gastrointestinal signs (24 of 30;80%) and pruritus (11 of 30;33%). In dogs with sterile neutrophilic dermatosis, five of 10 (50%) had diagnoses of or histories compatible with immune-mediated polyarthropathy. CONCLUSIONS AND CLINICAL IMPORTANCE: In this case series, CAEDE was encountered more frequently than neutrophilic dermatosis and could be distinguished by the eosinophilic infiltrate, aided by a Luna stain. Concurrent arthralgia was more frequently identified with neutrophilic dermatosis. It remains unclear whether CAEDE and sterile neutrophilic dermatosis are separate disease entities or varied manifestations of the same disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31486560/