Peer-reviewed veterinary case report
Cat with invasive Aspergillus felis infection treated with antifungals
By Cormack, Catherine A et al.·Published in Journal of veterinary internal medicine·2021·Department of Veterinary Clinical Sciences, China·View original on PubMed →
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Original publication title: Disseminated invasive aspergillosis caused by Aspergillus felis in a cat.
- Species:
- cat
Plain-English summary
A 2-year-old male Ragdoll cat was brought in for sneezing and nasal discharge, and a large lump was found in his neck. Further tests showed he had a serious fungal infection caused by Aspergillus felis, affecting his lymph nodes, sinuses, and lungs. The cat was treated with antifungal medications, which helped reduce some of the masses, but he continued to have issues with swallowing and eye problems. Sadly, he was euthanized 14 months later due to worsening symptoms, and further examination revealed extensive fungal damage.
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Abstract
A 2-year-old male desexed Ragdoll cat with a 1-year history of sneezing and nasal discharge presented with a large subcutaneous cervical mass, identified as the right medial retropharyngeal lymph node on computed tomography (CT). A right orbital mass, destructive sino-nasal cavity disease and multiple pulmonary nodules were also identified. Aspergillus felis was cultured from the lymph node. After treatment with posaconazole and liposomal amphotericin B the lymph node enlargement and orbital mass resolved but left frontal sinus involvement and pulmonary lesions persisted despite additional caspofungin therapy. The cat was euthanized 14 months after diagnosis with dysphagia and chronic progressive exophthalmos. A meningeal granuloma with intravascular fungal hyphae was identified at post-mortem and A felis was cultured from the left frontal sinus and a right retrobulbar fungal granuloma. This case demonstrates that disseminated disease is a possible sequel to invasive fungal rhinosinusitis caused by A felis in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34414603/