Peer-reviewed veterinary case report
Disseminated sclerosing peritoneal mesothelioma causing bleeding
By Gumber, Sanjeev et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2011·Department of Pathobiological Sciences, United States·View original on PubMed →
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Original publication title: Disseminated sclerosing peritoneal mesothelioma in a dog.
- Species:
- dog
Plain-English summary
A 7-year-old female German Shepherd was brought to the vet with unusual bruising and bleeding in her abdomen and vaginal area. Sadly, she was diagnosed with a severe internal bleeding condition and a large tumor in her abdomen, which turned out to be a type of cancer called malignant mesothelioma. This cancer had spread to other parts of her body, including her lungs and brain. Unfortunately, despite the diagnosis, the outcome was not favorable, and the dog did not survive.
People also search for: dog abdominal bleeding · German Shepherd cancer symptoms · mesothelioma in dogs treatment
Abstract
A 7-year-old female German Shepherd Dog was presented with multiple petechiae and ecchymoses along the ventral abdomen, flank, and on the vaginal mucosa. The clinical diagnosis was severe hemoperitoneum and presumed disseminated intravascular coagulopathy. Postmortem examination revealed a 22 cm × 15 cm × 6 cm, firm, and convoluted peritoneal mass along with hemoperitoneum, and multifocal, ill-defined, 0.5-1.5 cm in diameter, white to tan nodules in the pulmonary parenchyma. Histologically, the peritoneal mass was composed of large anaplastic cells consistent with malignant mesothelioma interspersed in abundant fibrous connective tissue. Metastasis of the neoplastic cells occurred to the brain, adrenal glands, lymph nodes, and lungs. On immunohistochemical evaluation, neoplastic cells coexpressed cytokeratin and vimentin, and were negative for cluster of differentiation (CD)18. Electron microscopy revealed numerous surface microvilli around the entire circumference of the neoplastic cells, as well as tight junctions, and desmosome-like structures. Based on test findings, a disseminated sclerosing peritoneal mesothelioma was diagnosed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21908373/