Peer-reviewed veterinary case report
Dog with severe colitis develops widespread infection and organ damage
By Curtis, Benjamin et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2020·Department of Microbiology, United States·View original on PubMed →
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Original publication title: Disseminatedinfection in a dog with severe colitis.
- Species:
- dog
Plain-English summary
A 12-year-old spayed female Schipperke was brought in with severe diarrhea for two months due to inflammatory bowel disease. Unfortunately, her condition worsened, leading to liver disease, pneumonia, and skin infections. Despite treatment with steroids, she developed severe complications, including extensive damage to her intestines and other organs. Sadly, she did not recover, and further tests revealed a parasitic infection that may have spread throughout her body due to the immunosuppressive medications.
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Abstract
A 12-y-old spayed female Schipperke dog with a previous diagnosis of inflammatory bowel disease was presented with a 2-mo history of severe colitis. The patient's condition progressed to hepatopathy, pneumonia, and dermatitis following management with prednisolone and dexamethasone sodium phosphate. Colonic biopsies identified severe necrosuppurative colitis with free and intracellular parasitic zoites. Postmortem examination confirmed extensive chronic-active ulcerative colitis, severe acute necrotizing hepatitis and splenitis, interstitial pneumonia, ulcerative dermatitis, myelitis (bone marrow), and mild meningoencephalitis with variable numbers of intracellular and extracellular protozoal zoites. PCR on samples of fresh colon was positive for. Immunohistochemistry identifiedtachyzoites in sections of colon, and a single tissue cyst in sections of brain. Administration of immunosuppressive drugs may have allowed systemic dissemination offrom the intestinal tract.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32954990/