Peer-reviewed veterinary case report
Cat with neurological signs linked to a unique feline coronavirus
By André, Nicole M et al.·Published in Journal of Feline Medicine and Surgery Open Reports·2019·Department of Microbiology & Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA, United States·View original on Crossref →
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Original publication title: Distinct mutation in the feline coronavirus spike protein cleavage activation site in a cat with feline infectious peritonitis-associated meningoencephalomyelitis
- Species:
- cat
Plain-English summary
A 5-year-old domestic shorthair cat was brought in for weight loss despite eating well and showed signs of anemia. Over three months, the cat developed coordination problems, weakness in its legs, and issues with bladder and bowel control. After further examination and tests, the cat was diagnosed with a severe neurological form of feline infectious peritonitis (FIP), which affected its brain and spinal cord. Unfortunately, the cat's condition was serious, and it did not recover after treatment.
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Abstract
Case summary This report describes a cat with chronic, progressive, non-painful, non-lateralizing multifocal neurologic clinical signs associated with feline infectious peritonitis (FIP). The cat initially presented as underweight, despite a good appetite, and a complete blood count showed non-regenerative anemia. Three months later the cat was returned having developed ataxia and paraparesis, which then progressed over 2 months to tetraparesis, tail plegia, urinary and fecal incontinence, and titubation. Histologic examination of the tissues with subsequent immunohistochemistry confirmed FIP-associated meningoencephalomyelitis following necropsy. Molecular analysis of the coronavirus spike protein within the tissues identified a specific, functionally relevant amino acid change (R793M), which was only identified in tissues associated with the central nervous system (ie, brain and spinal cord). Relevance and novel information This case report describes an early presentation of a cat with primarily neurologic FIP, with molecular characterization of the virus within various tissues.
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Search related cases →Original publication on Crossref: https://doi.org/10.1177/2055116919856103