Peer-reviewed veterinary case report
Distribution of DJ-1, Parkinson's disease-related protein PARK7, and its alteration in 6-hydroxydopamine-treated hemiparkinsonian rat brain.
- Journal:
- Journal of pharmacological sciences
- Year:
- 2006
- Authors:
- Yanagida, Takashi et al.
- Affiliation:
- Department of Neurobiology and 21st Century COE Program · Japan
- Species:
- rodent
Abstract
DJ-1 has multiple functions and its dysfunction may be linked to the onset of familial Parkinson's disease PARK7. However, the function and distribution of DJ-1 is unclear. In this study, we determined DJ-1 distribution and change after intranigral injection of 6-hydroxydopamine (6-OHDA). Although distribution of DJ-1 immunoreactivity was not changed in cerebral cortex and striatum, 6-OHDA caused increase of DJ-1 in the particulate fraction and decrease in the cytosolic fraction in substantia nigra. At that time, DJ-1 shifted to acid forms. These results suggest that distributional changes, translocation, and acidic shift of DJ-1 may be compensatory responses to protect against 6-OHDA-induced oxidative stress.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17038803/