Peer-reviewed veterinary case report
Two cats with different symptoms from FPV and FCoV coinfection
By Indarjulianto Soedarmanto et al.·Published in BIO Web of Conferences·2026·Department of Internal Medicine, Faculty of Veterinary Medicine, Universitas Gadjah Mada, FR·View original on DOAJ →
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Original publication title: Divergent Clinical Manifestations in Two Cats with FPV and FCoV Coinfection: A Case Report
- Species:
- cat
Plain-English summary
Two mixed-breed cats were brought to the vet with symptoms of not eating, vomiting, and diarrhea. The first cat, an 18-month-old male, had a high fever and very low white blood cell count, while the second cat, a 10-month-old female, had a low body temperature, moderate anemia, and also low white blood cell count. Tests confirmed that both cats were infected with Feline panleukopenia virus (FPV) and Feline coronavirus (FCoV) at the same time. While the sample size was small, these cases show that such coinfections can cause different symptoms and highlight the need for accurate testing to diagnose multiple viral infections in cats.
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Abstract
Concurrent infection of Feline panleukopenia virus (FPV) and Feline coronavirus (FCoV) is rarely documented in cats and current knowledge is largely limited to isolated case observations. This report describes the clinical, hematological, and molecular features of two cats with confirmed FPV–FCoV coinfection. Two mixed-breed cats presenting with anorexia, vomiting, and diarrhea were physically examined and screened using a rapid test kit. Hematological parameters were evaluated, and molecular assays (PCR/RT-PCR) were performed to confirm the diagnosis. Cat 1 (an 18-month-old male) presented with acute hyperthermia (40.1°C) and severe leukopenia (WBC 0.16 × 109/L), while Cat 2 (10-month-old female) presented with hypothermia (36.1°C), moderate anemia (RBC 4.7 ×10⁶/µL; HCT 30%), and leukopenia (WBC 1.5 ×10⁹/L). Molecular assays confirmed FPV and FCoV coinfection in both cats. Although limited by the very small sample size (n = 2), these cases illustrate heterogeneous clinical and hematological manifestations of FPV–FCoV coinfection, ranging from profound leukopenia without anemia to combined anemia and leukopenia. These findings may not intended to be generalized, but emphasize the potential immunosuppressive impact of viral coinfection and highlight the importance of molecular confirmation in multiple feline viral infections. This report contributes the preliminary observational data to the limited literature on FPV–FCoV coinfection in cats.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1051/bioconf/202622902001