Peer-reviewed veterinary case report
DNA vaccines and their applications in veterinary practice: current perspectives.
- Journal:
- Veterinary research communications
- Year:
- 2008
- Authors:
- Dhama, K et al.
- Affiliation:
- Indian Veterinary Research Institute · India
- Species:
- dog
Plain-English summary
Researchers are exploring a new type of vaccine called DNA vaccines, which use a piece of genetic material to help animals build immunity against infections. These vaccines have some advantages, like being stable, cost-effective, and not needing to be kept cold, which makes them promising for preventing diseases in pets and livestock. However, there are still many challenges to overcome, such as how to deliver the vaccine effectively and how to ensure it triggers a strong immune response. Ongoing studies are looking into improving these vaccines for various diseases that affect both humans and animals. Overall, while DNA vaccines show potential, more research is needed to make them a practical option for widespread use in veterinary medicine.
Abstract
Inoculation of plasmid DNA, encoding an immunogenic protein gene of an infectious agent, stands out as a novel approach for developing new generation vaccines for prevention of infectious diseases of animals. The potential of DNA vaccines to act in presence of maternal antibodies, its stability and cost effectiveness and the non-requirement of cold chain have heightened the prospects. Even though great strides have been made in nucleic acid vaccination, still there are many areas that need further research for its wholesome practical implementation. Major areas of concern are vaccine delivery, designing of suitable vectors and cytotoxic T cell responses. Also, the induction of immune responses by DNA vaccines is inconclusive due to the lack of knowledge regarding the concentration of the protein expressed in vivo. Alternative delivery systems having higher transfection efficiency and the use of cytokines, as immunomodulators, needs to be further explored. Recently, efforts are being made to modulate and prolong the active life of dendritic cells, in order to make antigen presentation a more efficacious one. For combating diseases like acquired immunodeficiency syndrome (AIDS), influenza, malaria and tuberculosis in humans; and foot and mouth disease, Aujesky's disease, swine fever, rabies, canine distemper and brucellosis in animals, DNA vaccine clinical trials are underway. This review highlights the salient features of DNA vaccines, and measures to enhance their efficacy so as to devise an effective and novel vaccination strategy against animal diseases.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18425596/