Peer-reviewed veterinary case report
Does sodium thiosulphate delay presbyacusis?
- Journal:
- Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
- Year:
- 2010
- Authors:
- Quddusi, Taeed et al.
- Affiliation:
- Department of Otolaryngology-Head and Neck Surgery
- Species:
- rodent
Abstract
INTRODUCTION: This study compares the effects of sodium thiosulphate (STS) and normal saline on the prevention of hearing loss. SETTING: Animal research laboratory. METHODS: Sixteen mice were randomized to receive intraperitoneal injections of either normal saline or STS. Auditory brainstem response testing was used to determine baseline and posttreatment hearing thresholds over the course of 1 year. RESULTS: Compared with saline, treatment with STS resulted in a statistically significant improvement in click and pure-tone thresholds until the end of the year. CONCLUSION: STS can significantly delay hearing loss associated with age in this murine model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20643009/