Peer-reviewed veterinary case report
Does sweet turn sour? How aspartame aggravates atherosclerosis in a preclinical model.
- Journal:
- Cell metabolism
- Year:
- 2025
- Authors:
- Pepino, M Yanina & Amengual, Jaume
- Affiliation:
- Department of Food Science and Human Nutrition · United States
Abstract
Aspartame, a low-calorie sweetener (LCS), was shown to be safe through extensive pre-clinical and clinical tests. However, epidemiological data link aspartame and other LCSs to higher cardiovascular risk. In this issue of Cell Metabolism, Wu et al.show that aspartame accelerates atherosclerosis via a vagal-mediated insulin-dependent mechanism in a hyperlipidemic mouse model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40334641/