Peer-reviewed veterinary case report
Dolabellane Diterpenoids from Soft Coral <i>Clavularia viridis</i> with Anti-Inflammatory Activities.
- Year:
- 2025
- Authors:
- Gu C et al.
- Affiliation:
- Peking University · China
Abstract
A chemical investigation of the EtOAc fraction from soft coral <i>Clavularia viridis</i> resulted in the isolation of 12 undescribed dolabellane-type diterpenoids, namely clavirolides W-Z (<b>1</b>-<b>4</b>), clavularols A-H (<b>5</b>-<b>12</b>), and three known analogs (<b>13</b>-<b>15</b>). Their structures were characterized by an extensive analysis of spectroscopic data, including X-ray diffraction and ECD calculations for the assignment of absolute configurations. The structures of <b>2</b> and <b>4</b>-<b>6</b> are feathered as peroxyl-substituted derivatives, while compounds <b>7</b>-<b>12</b> possess additional oxidative cyclization, including epoxide or furan that are rare in the dolabellane family. All these compounds were evaluated for activities on cytotoxic and anti-inflammatory models. Compound <b>10</b> exhibited most potential against NO production in the BV2 cell induced by LPS with an IC<sub>50</sub> value of 18.3 μM.
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Search related cases →Original publication: https://europepmc.org/article/MED/40863628