Peer-reviewed veterinary case report
Cat hepadnavirus linked to liver disease in cats
By Piewbang, Chutchai et al.·Published in Journal of veterinary internal medicine·2022·Department of Pathology·View original on PubMed →
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Original publication title: Domestic cat hepadnavirus associated with hepatopathy in cats: A retrospective study.
- Species:
- cat
Plain-English summary
A group of cats in Thailand were tested for a virus called domestic cat hepadnavirus (DCH) after showing signs of liver problems. Out of 661 cats, 103 tested positive for DCH, and these cats had significantly higher levels of liver enzymes, indicating liver damage. Some of the affected cats were diagnosed with acute or chronic hepatitis, which is inflammation of the liver. The study found that the presence of DCH was linked to more severe liver issues. If your cat is showing signs of liver disease, such as jaundice or lethargy, it's important to discuss these findings with your veterinarian for appropriate testing and treatment options.
People also search for: cat liver disease symptoms · domestic cat hepadnavirus · cat hepatitis treatment · high liver enzymes in cats · what to do for cat with liver problems
Abstract
BACKGROUND: Whether domestic cat hepadnavirus (DCH) infection is associated with clinical disease remains to be determined. OBJECTIVES: To determine the relationship between DCH detection, hematology, serum bichemistry and liver histology in DCH-positive cats. ANIMALS: One thousand twenty-two cats in Thailand without concurrent diseases and not undergoing treatments adversely affecting the liver. METHODS: Retrospective cross-sectional study. Samples derived from cats with concurrent virus detection were excluded. DCH detection was determined in blood and fresh-frozen liver by quantitative polymerase chain reaction (qPCR) and further investigated in liver sections showing histological parenchymal disorders (HPD) and normal liver (HNL) using in situ hybridization (ISH). Proliferative/apoptotic activities were determined using immunohistochemistry and ISH panels. Biochemical variables and risk factors for DCH infection were investigated. RESULTS: Six hundred sixty-one (557 blood and 119 liver samples) cats were included. DCH was detected in 18.50% (103/557), 13.85% (9/65), and 3.70% (2/54) of the blood, HPD, and HNL groups, respectively. Cats with DCH revealed abnormally high activity of aspartate aminotransferase (AST) (P = .001) and alanine aminotransferase (ALT) (P < .001). Among DCH-positive HPD case 2/9 an 7/9 were acute and chronic hepatitis, of which 4/7 had hepatitis. Log viral copy number (LVCN) was positively correlated with ALT (P < .001), triglyceride (P < .001), and gamma-glutamyl transpeptidase (GGT) (P = .022). The LVCN also had a positive association with degree of hepatitis (P < .05). There was hepatocyte proliferation activity in DHC positive cats. CONCLUSION AND CLINICAL IMPORTANCE: Domestic cat hepadnavirus infection was associated with high serum activity of liver enzymes and chronic lymphoplasmacytic hepatitis (LPH).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36054642/