Peer-reviewed veterinary case report
Donkey antibody treatment improves survival in dogs with distemper
By Zhang, Jianlou et al.·Published in BMC veterinary research·2021·School of Veterinary Medicine, China·View original on PubMed →
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Original publication title: Donkey-derived anti-CDV IgG, as a passive immunotherapy agent, can effectively increase survival rates of the experimental CDV-infected dogs.
- Species:
- dog
Plain-English summary
A group of Shih Tzu dogs infected with canine distemper virus (CDV) showed severe symptoms, but treatment with a special antibody derived from donkeys significantly improved their condition. This donkey-derived antibody helped reduce the virus's ability to replicate and eased the dogs' clinical symptoms, leading to a survival rate of 75%. This promising treatment could provide an alternative for dogs suffering from CDV when traditional dog-derived antibodies are not available.
People also search for: dog distemper treatment · Shih Tzu distemper symptoms · donkey-derived antibody for dogs
Abstract
BACKGROUND: Humoral immunity plays an important role in the prevention of canine distemper. Anti-CD virus (CDV) antibody has strong antiviral activity and is widely used in the treatment of CD. However, with the increase of CD cases, the availability of therapeutic CD antibody fell short of the clinical needs. RESULTS: The high-titer antiserum with the high-titer neutralizing activity against CDV was obtained from the donkeys (Dezhou Donkey) immunized with the inactivated CDV vaccine. The donkey anti-CDV IgG was purified from the donkey serum, which was identified to significantly inhibit the CDV replication in the cultured Vero cells and effectively reduce the clinical symptoms and increase the survival rates (75%) of CDV-infected dogs (Shih-tzu Dog), similar to that treated with the dog-derived anti-CDV IgG. These results indicate that donkey-derived IgG is a potential substitute for dog-derived IgG to treat the CD in clinic. CONCLUSIONS: Administration of donkey-derived anti-CDV IgG can ameliorate clinical symptoms and inhibit virus replication, thereby increasing the survival of CDV-infected dogs. This study opens up a new source of therapeutic antibody for CD treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34362358/