Peer-reviewed veterinary case report
Neurological symptoms and death in kittens after doramectin treatment
By Nentwig, A et al.·Published in Schweizer Archiv fur Tierheilkunde·2014·Departement fü·View original on PubMed →
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Original publication title: [Doramectin intoxication in 3 kittens].
- Species:
- cat
Plain-English summary
Three kittens from the same litter were brought in after showing signs of doramectin (a medication) toxicity. Two of the kittens had mild symptoms like apathy and tremors, and one experienced seizures that were treated successfully with diazepam. Both of these kittens made a full recovery. Unfortunately, a third kitten was found in a coma three days after receiving the same treatment and later died despite efforts to help. The examination revealed severe brain damage due to the high dose of doramectin it received.
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Abstract
This case report describes 3 kittens with suspected doramectin toxicity. In a litter of 7 kittens treated with doramectin, 3 developed neurological symptoms. One kitten showed mild apathy and tremors, while a second one additionally presented behavioral changes and seizures that had to be treated with diazepam. Both kittens recovered completely. A third kitten was presented to us in coma 3 days following treatment with doramectin. Subsequently, this kitten developed behavioral changes such as aggression, hyperesthesia, tremors, and seizures and died 36 hours after presentation. Histopathologic examination of the brain showed cytotoxic edema and polioencephalomalacia. The doramectin dosage of the deceased kitten was 380 μg/kg.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24686818/