Peer-reviewed veterinary case report
Safe and effective 2% chlorhexidine dose for dog skin infections
By Murayama, Nobuo et al.·Published in Veterinary dermatology·2011·ASC Dermatology Service, Japan·View original on PubMed →
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Original publication title: Dose assessment of 2% chlorhexidine acetate for canine superficial pyoderma.
- Species:
- dog
Plain-English summary
A group of dogs with skin infections called superficial pyoderma were treated with a 2% chlorhexidine solution to see how much was needed for effective results. The dogs received the treatment every two days for a week, and their skin conditions were evaluated by both their owners and veterinarians. The study found that there wasn't a significant difference in improvement among the different doses used. However, a practical method was established for owners to apply the treatment, suggesting they use an amount similar to a Japanese coin for each two-hand-sized area of infection.
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Abstract
The dose of 2% chlorhexidine acetate (2CA; Nolvasan(®) Surgical Scrub; Fort Dodge Animal Health, Fort Dodge, IA, USA) for canine superficial pyoderma was evaluated. The first trial compared three doses (group 1, 57 mL/m(2) body surface area; group 2, 29 mL/m(2) body surface area; and group 3, 19 mL/m(2) body surface area) in a randomized, double-blind, controlled fashion. Twenty-seven dogs with superficial pyoderma were treated with 2CA at the allocated doses every 2 days for 1 week. The owners and investigators subjectively evaluated the dogs, and investigators scored skin lesions, including erythema, papules/pustules, alopecia and scales, on a 0-4 scale. There were no significant differences in response between the treatment groups. The second trial established a practical dose-measuring method for 2CA. Sixty-eight owners were asked to apply 2CA on their palm in an amount corresponding to a Japanese ¥500 coin, 26.5 mm in diameter. This yielded an average dose of 0.90±0.40 mL. Mathematically, the doses used in groups 1, 2 and 3 can be represented as one coin per approximately one-, two- and three-hand-sized lesions, respectively. The results therefore suggest that owners instructed to apply one coin of the product per two-hand-sized areas of superficial pyoderma would use the range of doses evaluated in this trial.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21392140/