Peer-reviewed veterinary case report
Dose dependence and therapeutic window for the neuroprotective effects of 17beta-estradiol when administered after cerebral ischemia.
- Journal:
- Neuroscience letters
- Year:
- 2007
- Authors:
- Liu, Ran et al.
- Affiliation:
- Department of Pharmacology and Neuroscience · United States
- Species:
- rodent
Abstract
The present study was undertaken to determine if the neuroprotective effect of 17beta-estradiol (E(2)) when administrated after ischemia is dose-dependent and if the therapeutic window for estrogen can be prolonged. Ischemic injury was induced by permanent middle cerebral artery occlusion (p-MCAO). Administration of E(2) at 30 min after ischemia resulted in a reduction in lesion volume. A higher dose of E(2) extended the therapeutic window to 6h after cerebral ischemia in 33% of the rats. These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17331646/