Peer-reviewed veterinary case report
How long does liposomal bupivacaine relieve horse leg pain
By Dockery, Allison et al.·Published in American journal of veterinary research·2024·View original on PubMed →
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Original publication title: Dose effect and duration of action of liposomal bupivacaine administered as a perineural analgesic in a reversible and adjustable frog-pressure model of equine lameness.
- Species:
- horse
Plain-English summary
A group of 12 healthy adult horses had lameness induced in one front leg to test the effects of a pain relief injection called liposomal bupivacaine. The horses received either a low dose or a high dose of the medication, and both doses helped reduce lameness and improve sensitivity in the affected leg. The low dose provided relief for about 4.5 hours, while the high dose lasted around 12 hours before the horses started showing signs of lameness again. Most horses experienced some mild swelling at the injection site, but overall, both doses were effective in managing pain.
People also search for: horse lameness treatment · liposomal bupivacaine for horses · equine pain relief options
Abstract
OBJECTIVE: To determine the dose effect of peri-neural liposomal bupivacaine (LB) in an induced forelimb lameness model. ANIMALS: 12 clinically normal adult horses. METHODS: A randomized cross-over design was performed with 1 limb receiving saline and the other LB: low dose (6), high dose (6). Lameness was induced in 1 forelimb using a frog-pressure model. In the lame limb, peri-neural injection of the palmar nerves at the proximal sesamoid bones was performed using saline, low dose LB (0.25 mg/kg) (LDLB), or high dose LB (0.5mg/kg) (HDLB) in random order with a 1-week washout period between treatments. Distal limb swelling, mechanical nociceptive thresholds (MNT), and objective lameness data were collected before and up to 72 hours after peri-neural anesthesia. Data analysis was performed with mixed model ANOVA, equality of medians test, and Kaplan Meier survival analysis. RESULTS: Compared with baseline, horses treated with LDLB and HDLB had improvements in MNT and lameness (P < .001). In the LDLB group, the median duration of analgesia was 4.5 hours (range = 3-6 hours) and the median return to lameness was 7 hours (range = 4-24 hours). In the HDLB group, the median duration of analgesia was 12 hours (range = 4-48 hours) and the median return to lameness was 9 hours (range = 3-48 hours). Mild to moderate swelling was identified in 11/12 (92%) LB limbs. CLINICAL RELEVANCE: Both LDLB and HDLB resulted in loss of skin sensation and improvement of lameness. There was high variability among horses in duration of action for both doses.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38171091/