Peer-reviewed veterinary case report
How travoprost eye drops lower pressure in glaucomatous Beagles
By Mackay, Edward O et al.·Published in Veterinary ophthalmology·2012·Department of Small Animal Clinical Sciences and Gwathmey-Adams Laboratory for Vision Research, United States·View original on PubMed →
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Original publication title: Dose response for travoprost® in the glaucomatous beagle.
- Species:
- dog
Plain-English summary
Twelve Beagles with inherited glaucoma were treated with different concentrations of travoprost eye drops to see how well they could lower eye pressure and affect pupil size. The results showed that concentrations of 0.00033%, 0.001%, and 0.0033% significantly reduced eye pressure, while the lowest concentration of 0.0001% had little effect on eye pressure but still changed pupil size. This means that travoprost can effectively help manage glaucoma in dogs, even at very low doses.
People also search for: beagle glaucoma treatment · travoprost for dogs · dog eye pressure medication
Abstract
OBJECTIVE: To evaluate the changes in intraocular pressure (IOP) and pupil size in 12 Beagles with inherited glaucoma after instillations of 0.033, 0.0033, 0.001, 0.00033, and 0.0001% travoprost (Travatan®-Alcon Laboratories, Inc., Ft Worth, TX, USA) in multiple single-dose studies. PROCEDURES: Intraocular pressure and pupil diameter (PD) measurements were obtained at 9 am, 12 pm, 3 pm, and 9 am the following day (24 h) in two groups of six glaucoma dogs. After 7 days, the vehicle or concentration was repeated in the contralateral eye of the same animals. RESULTS: Concentrations of 0.00033, 0.001, and 0.0033% travoprost significantly lowered IOP and PD, but the 0.0001% concentration provided limited IOP changes, although PD changes were still significant. This suggests travoprost is effective in the dog to lower IOP and reduce pupil size at concentrations starting between 0.0001 and 0.00033%. CONCLUSIONS: The dose response for travoprost in the glaucomatous Beagle indicates this model is highly sensitive to this group of drugs, even at concentrations as low as 0.00033% (1/12 the commercially available concentration).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22050687/