Peer-reviewed veterinary case report
Dose response of the AIA rabbit stifle joint to boron neutron capture synovectomy.
- Journal:
- Nuclear medicine and biology
- Year:
- 2004
- Authors:
- Shortkroff, Sonya et al.
- Affiliation:
- Department of Orthopaedic Surgery · United States
- Species:
- rabbit
Abstract
This study assessed the treatment with boron neutron capture synovectomy of synovitis in the antigen-induced arthritis (AIA) model. A boron compound, potassium dodecahydrododeca-borate (K(2)B(12)H(12)), was injected into stifle joints of 24 AIA and 12 normal rabbits and activated by neutron bombardment of the joint to achieve doses from 800 to 81,000 RBE-cGy. Synovial ablation in the AIA joint was accomplished at doses of 6,000 to 7,000 RBE-cGy with no adverse effects to skin or extracapsular tissues.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15219286/