Peer-reviewed veterinary case report
Topical cannabinoid treatment reduces itching in atopic Beagles
By Marsella, Rosanna et al.·Published in Archives of dermatological research·2019·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Double blinded, vehicle controlled, crossover study on the efficacy of a topical endocannabinoid membrane transporter inhibitor in atopic Beagles.
- Species:
- dog
Plain-English summary
A group of Beagles with atopic dermatitis (a skin allergy) were treated with a new topical gel designed to reduce itching and inflammation. Over the course of the study, the dogs that received the active gel showed significantly less itching and skin irritation compared to those that received a placebo gel. The treatment was applied twice daily for four weeks, and no side effects were reported. This suggests that the new gel could be an effective option for managing skin allergies in dogs.
People also search for: Beagle skin allergy treatment · dog itching relief · atopic dermatitis in dogs · topical treatment for dog skin problems
Abstract
The endocannabinoid system is important for skin homeostasis and alterations are linked to inflammatory diseases like atopic dermatitis (AD). Importantly, activation of cannabinoid receptor CB2 decreases pruritus and inflammation in mouse models. Reduction of inactivation of endogenous cannabinoids could, therefore, be a therapeutic option for AD. Dogs spontaneously develop AD, which closely mimics the human disease making them suitable to test new therapies. Our study aimed to test the effects of a topical endocannabinoid membrane transporter inhibitor (WOL067-531, 1% gel) on pruritus and dermatitis in a canine model of AD. Nineteen Beagles allergic to dust mites (DM) were randomized to receive either active ingredient or vehicle on inguinal area while challenged epicutaneously with DM twice weekly for 28 days. Treatment was administered twice daily and started after three challenges (day 8). Dermatitis and pruritus were scored weekly by personnel blinded to treatment allocation. Dermatitis was scored using a validated scoring system and pruritus was scored using camera recordings. After a 4-week washout, dogs were crossed over and the study was repeated. On days 15 and 22, dermatitis scores were significantly increased after DM challenge in the vehicle group (16.34, p = 0.0089 and 7.42, p = 0.04845, respectively) but not in the active ingredient group (p = 0.3177 and p = 0.3190, respectively). Significant decrease on pruritus both on inguinal area and overall (p = 0.048 and p = 0.032, respectively) occurred in the active ingredient group. No adverse effects were noted. In conclusion, the newly developed topical endocannabinoid membrane transporter inhibitor (WOL067-531) minimized allergic flares and pruritus in a canine model of AD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31446453/