Peer-reviewed veterinary case report
Doxorubicin chemotherapy improves survival in dogs with heart
By Mullin, C M et al.·Published in Veterinary and comparative oncology·2016·The Oncology Service, United States·View original on PubMed →
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Original publication title: Doxorubicin chemotherapy for presumptive cardiac hemangiosarcoma in dogs.
- Species:
- dog
Plain-English summary
A group of 64 dogs diagnosed with suspected cardiac hemangiosarcoma (a type of cancer affecting the heart) were treated with a chemotherapy drug called doxorubicin. About 41% of the dogs showed a positive response to the treatment, and overall, 68% experienced some clinical benefit. On average, the dogs lived about 116 days after starting treatment, which is a significant improvement compared to just 12 days for dogs that did not receive treatment. The results suggest that doxorubicin can be effective for dogs with this serious condition.
People also search for: dog heart cancer treatment · doxorubicin for dogs · cardiac hemangiosarcoma prognosis
Abstract
Sixty-four dogs were treated with single-agent doxorubicin (DOX) for presumptive cardiac hemangiosarcoma (cHSA). The objective response rate (CR + PR) was 41%, and the biologic response rate (CR + PR + SD), or clinical benefit, was 68%. The median progression-free survival (PFS) for treated dogs was 66 days. The median survival time (MST) for this group was 116 days and was significantly improved compared to a MST of 12 days for untreated control dogs (P = 0.0001). Biologic response was significantly associated with improved PFS (P < 0.0001) and OS (P < 0.0001). Univariate analysis identified larger tumour size as a variable negatively associated with PFS. The high rate of clinical benefit and improved MST suggest that DOX has activity in canine cHSA.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25524594/