Peer-reviewed veterinary case report
Drug residues found in blood of dogs after cancer chemo
By Knobloch, A et al.·Published in Journal of veterinary internal medicine·2010·Small Animal Hospital, Germany·View original on PubMed →
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Original publication title: Drug residues in serum of dogs receiving anticancer chemotherapy.
- Species:
- dog
Plain-English summary
A group of 27 dogs undergoing chemotherapy for lymphoma or mast cell tumors had their blood tested for drug residues after treatment. The study found that while high levels of chemotherapy drugs like vincristine and cyclophosphamide were present shortly after treatment, only trace amounts were detected in samples taken 7 days later. This suggests that handling blood from these dogs a week after their chemotherapy is safe and does not pose a health risk.
People also search for: dog chemotherapy side effects · lymphoma treatment in dogs · mast cell tumor treatment for dogs
Abstract
BACKGROUND: The presence of drug residues in blood samples can represent an occupational hazard. However, studies on cytotoxic drug residues in serum of dogs are lacking in veterinary oncology. OBJECTIVE: To evaluate possible occupational hazards associated with handling of blood samples from dogs receiving oncolytic drugs 7 days after treatment. ANIMALS: Twenty-seven client-owned dogs treated for lymphoma or mast cell tumors with vincristine, vinblastine, cyclophosphamide, or doxorubicin. METHODS: Prospective, observational study. Serum samples were either taken 7 days after administration of vincristine, cyclophosphamide, doxorubicin (lymphoma), and vinblastine (mast cell tumor), or 1-2 days after the last concurrent oral administration of cyclophosphamide (mast cell tumor). Additionally, serum was collected within 5 minutes of treatment. Measurement of drug residues in serum was performed by liquid chromatography tandem mass spectrometry (LC/MS/MS). RESULTS: In 33 samples collected within 5 minute of treatment, the median serum concentrations were vincristine: 37 microg/L (range: 11-87 microg/L), vinblastine: 13 microg/L (range: 13-35 microg/L), cyclophosphamide: 2,484 microg/L (range: 1,209-2,778 microg/L), doxorubicin: 404 microg/L (range: 234-528 microg/L). In 81 serum samples collected 7 days after treatment vinblastine (7 microg/L) was detected in 1 sample, and cyclophosphamide (7 and 9 microg/L) in 2 samples collected 1-2 days after oral administration of cyclophosphamide. Medications were not detected in any of the other samples. CONCLUSIONS AND CLINICAL IMPORTANCE: Handling of blood samples from dogs receiving oncolytic chemotherapy 7 days after treatment with vincristine, vinblastine, cyclophosphamide, and doxorubicin should not present a health hazard.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20102504/