Peer-reviewed veterinary case report
Drug screening for Huntington's disease and other neurodegenerative disorders.
- Journal:
- Current molecular pharmacology
- Year:
- 2010
- Authors:
- Varma, Hemant
- Affiliation:
- Department of Biological Sciences · United States
Abstract
Devising therapies for neurodegenerative diseases remains a major challenge due to the complex etiology, prolonged disease course and the paucity of validated targets. These factors make it difficult to model neurodegenerative diseases in a manner amenable to large-scale screening. However recent developments in automation, combinatorial chemistry and high-throughput phenotypic assays have presented new opportunities for discovering small molecule therapeutics for neurodegenerative diseases. This review focuses on novel in vitro and phenotypic screens for Huntington's disease and a few other neurodegenerative diseases. The lessons learned from these screens and the potential of the small molecules identified as therapeutic leads are discussed.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20858196/