Peer-reviewed veterinary case report
Signs and outcomes after duloxetine poisoning in 364 dogs
By James, Natalie K et al.·Published in Journal of the American Veterinary Medical Association·2019·View original on PubMed →
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Original publication title: Duloxetine ingestion in 364 dogs.
- Species:
- dog
Plain-English summary
A group of 364 dogs accidentally ingested a medication called duloxetine, which can cause various symptoms. About 15% of these dogs showed signs of illness, with the most common symptoms being lethargy, dilated pupils, vomiting, and trembling. Dogs that ate higher doses (20 mg/kg or more) were more likely to show these symptoms. Fortunately, most dogs did not experience any serious effects and many fully recovered. If your dog has ingested duloxetine, it's important to contact your veterinarian for advice.
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Abstract
OBJECTIVE: To describe abnormal clinical signs following duloxetine ingestion in dogs. ANIMALS: 364 client-owned dogs that ingested duloxetine. PROCEDURES: The American Society for the Prevention of Cruelty to Animals, Animal Poison Control Center electronic database was searched for records of dogs with duloxetine ingestion between January 2012 and December 2016. Data collected included age, body weight, breed, duloxetine exposure and dose, clinical signs, and overall outcome. Clinical signs were categorized as either neurologic, digestive, cardiovascular, respiratory, or metabolic and endocrine. Outcomes were categorized as no clinical signs, fully recovered, died, or unknown. RESULTS: Clinical signs developed in 55 of the 364 (15.1%) dogs with known ingestion of duloxetine. The most common clinical signs were lethargy (22/55 [40%]), mydriasis (18/55 [33%]), vomiting (11/55 [20%]), and trembling (6/55 [11%]). Dogs that ingested an estimated dose of duloxetine ≥ 20 mg/kg (9.1 mg/lb) were more likely to have had abnormal clinical signs than were dogs that ingested < 20 mg/kg. CONCLUSIONS AND CLINICAL RELEVANCE: Findings indicated that most dogs in the present study did not have clinical signs associated with ingestion of duloxetine and that development of clinical signs varied by individual dog. Further information is needed to determine toxic dose ranges for duloxetine ingestion in dogs. (2019;255:1161-1166).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31687894/