Peer-reviewed veterinary case report
Hair ridge and dermoid sinus linked to gene duplication in Ridgeback
By Salmon Hillbertz, Nicolette H C et al.·Published in Nature genetics·2007·Department of Animal Breeding and Genetics·View original on PubMed →
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Original publication title: Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs.
- Species:
- dog
Plain-English summary
Rhodesian Ridgeback dogs have a unique hair ridge along their back, but this trait is linked to a genetic mutation that can also lead to a skin issue called dermoid sinus, which is a congenital condition. Researchers found that this mutation involves a duplication of certain genes that are important for development. This means that the hair ridge and the risk of developing dermoid sinus are connected to how these genes function during the dog's growth. Understanding this genetic link can help breeders and owners be more aware of potential health issues in Ridgebacks.
People also search for: Rhodesian Ridgeback hair ridge problems · dermoid sinus in dogs · genetic issues in Ridgeback dogs
Abstract
The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17906623/