Peer-reviewed veterinary case report
Rocuronium causes shorter and less predictable muscle block than
By Martin-Flores, Manuel et al.·Published in Veterinary ophthalmology·2023·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Duration of neuromuscular block is more variable and recovery time is shorter with rocuronium than cisatracurium in anesthetized dogs.
- Species:
- dog
Plain-English summary
Thirty dogs undergoing eye surgery were given either rocuronium or cisatracurium to help relax their muscles during anesthesia. The study found that while rocuronium worked faster, its effects were more unpredictable compared to cisatracurium, which had a more consistent duration. Dogs that received rocuronium took about 15 minutes to recover on their own, while those given cisatracurium took around 25 minutes. This suggests that while rocuronium may be quicker, it can lead to longer and more variable recovery times, so careful monitoring is important during anesthesia.
People also search for: dog anesthesia recovery time · rocuronium vs cisatracurium for dogs · dog eye surgery anesthesia
Abstract
OBJECTIVE: To compare the variability in the duration of action of a single dose of rocuronium or cisatracurium, and duration of subsequent top-up doses in anesthetized dogs. ANIMALS: Thirty dogs requiring ophthalmic surgery with neuromuscular block. PROCEDURES: Neuromuscular function was monitored with train-of-four (TOF) and acceleromyography. Dogs received an initial dose of rocuronium 0.6 mg/kg, or cisatracurium 0.15 mg/kg IV, which produced complete neuromuscular block. Upon return of the first response (T1) of TOF, a third of the initial dose was repeated. The duration of the initial dose and its variability were compared between agents. Duration of subsequent top-up doses was assessed with mixed effect models. Spontaneous (from last return of T1) or neostigmine-enhanced (from administration to complete recovery) recovery times were measured for each agent. RESULTS: Duration of action of the initial dose was [median (range)] 25 (10-60) min with rocuronium and 35 (15-45) min with cisatracurium (p = .231). The variability of rocuronium was 3.25 times larger than cisatracurium (p = .034). Duration of top-up doses did not vary for either agent. Spontaneous recovery was shorter for rocuronium [15 (10-20) min] than cisatracurium [25 (15-45) min] (p = .02). Neostigmine-enhanced recovery times were 5 (5-25) for rocuronium and 10 (5-10) for cisatracurium (p = .491). CONCLUSIONS: Duration of action for a single dose is significantly more variable with rocuronium than cisatracurium. Time to spontaneous recovery was longer for cisatracurium, and cases of unexpectedly long recovery times were observed with both agents. Objective monitoring is recommended.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36799561/