Peer-reviewed veterinary case report
Dwarfism and hair loss in Tibetan Terrier dogs with gene mutation
By Thaiwong, Tuddow et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2021·Veterinary Diagnostic Laboratory, United States·View original on PubMed →
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Original publication title: Dwarfism in Tibetan Terrier dogs with anmutation.
- Species:
- dog
Plain-English summary
A group of Tibetan Terrier puppies were born healthy but didn't grow or gain weight like their siblings, raising concerns for their owners. It was discovered that these puppies had a genetic mutation linked to dwarfism, which is inherited from their parents. This mutation caused them to remain smaller than normal and resulted in abnormal fur that didn't transition to the adult coat. Identifying this genetic issue can help breeders make informed decisions to prevent dwarfism in future litters.
People also search for: Tibetan Terrier dwarfism symptoms · puppy not gaining weight · dog genetic mutation dwarfism
Abstract
Canine pituitary dwarfism in German Shepherd and related dog breeds has been reported to be associated with a 7-bp deletion mutation in intron 5 of thegene. This mutation is transmitted as an autosomal recessive trait that results in dwarf dogs with significantly smaller stature and abnormal haircoat, and potentially early death. Phenotypically, affected adult dogs are proportionally dwarfs. These dwarfs also have a soft, woolly puppy coat that fails to transition into the typical adult hair coat, and marked hair loss occurs in some dogs. We report a similar manifestation of dwarfism in Tibetan Terriers with the samemutation. Dwarf Tibetan Terrier puppies were born physically normal but failed to gain weight or to grow at the same rate as their normal littermates. The 7-bp deletion mutation of thegene was identified in both alleles of 3 Tibetan Terrier dwarfs from 3 litters, which were biologically related. All parents of these dogs are carriers, confirming transmission of dwarfism in an autosomal recessive manner. Recognition and detection of this mutation will help in guiding future breeding plans to eventually eliminate this trait from Tibetan Terriers.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33890524/