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Peer-reviewed veterinary case report

Dynamic Involvement of Striatal NG2-glia in L-DOPA Induced Dyskinesia in Parkinsonian Rats: Effects of Doxycycline.

Journal:
ASN neuro
Year:
2023
Authors:
Nascimento, G C et al.
Affiliation:
Department of Oral and Basic Biology · Brazil
Species:
rodent

Abstract

NG2-glia alters its dynamics in response to L-DOPA-induced dyskinesia. In these animals, striatal NG2-glia density was reduced with cells presenting activated phenotype while doxycycline antidyskinetic therapy promotes a return to NG2-glia cell density and protein to a not activated state.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/37017068/