Peer-reviewed veterinary case report
Dynamics of morphofunctional changes in immune organs of BALB/c mice with experimental hepatitis.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2006
- Authors:
- Obernikhin, S S et al.
- Affiliation:
- Institute of Human Morphology
- Species:
- rodent
Abstract
The time course of morphofunctional changes in the liver, thymus, and spleen was observed in BALB/c mice with Con A-induced experimental hepatitis. The progress of alterative changes in the liver was paralleled by intensification of accidental involution of the thymus. On day 1 of hepatitis development high proliferative and cytostatic activity of splenocytes was paralleled by hemorrhagic necroses and depletion of the peri-arteriolar lymphoid sheaths in the spleen (T-zones), presumably due to migration of activated lymphocytes to the liver and barrier tissues. Later normalization of lymphocyte proliferative activity was paralleled by recovery and hyperplasia of the splenic T-cell zones.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17152372/